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KMID : 0191120100250121727
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Journal of Korean Medical Science
2010 Volume.25 No. 12 p.1727 ~ p.1732
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Immunogenicity and Safety of Diphtheria-tetanus Vaccine in Adults
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Choi Jung-Hyun
Choo Eun-Ju
Huh Ae-Jung
Choi Su-Mi
Eom Joong-Sik
Lee Jin-Seo
Park Sun-Hee
Kang Jin-Han
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Abstract
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This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and tetanus, respectively, which were below protective level (<0.1 U/mL). After the first dose of Td vaccine, 92.6% and 77.6% of subjects gained protective antibody concentrations (≥0.1 U/mL) for diphtheria and tetanus, with an increase to 99.6% and 100% after the third dose. Local and systemic adverse events occurred in 37.9% and 15.5% of the subjects. No serious adverse event requiring an unscheduled hospital visit occurred. In conclusion, three-doses of Td vaccination to unimmunized adults are safe and effective in inducing protective immunity against diphtheria and tetanus.
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KEYWORD
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Diphtheria, Tetanus, Vaccines, Immunogenicity, Safety, Adult
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